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Size Differentiation and Absolute Quantification of Gold Nanoparticles via Single Particle Detection with a Laboratory-Built High-Sensitivity Flow Cytometer
【来源】:本站原创 【发表时间】:2012-11-27 【浏览次数】:1767

Abstract   Employing single nanoparticle detection with a laboratory-built high-sensitivity flow cytometer, we developed a simple and versatile platform that is capable of detecting the surface plasmon resonance scattering of gold nanoparticles (GNPs) as small as 24 nm, differentiating GNPs of different sizes, and providing accurate quantification of GNPs. Low-concentration samples (fM to pM) in small volumes (μL) can be measured in minutes with an analysis rate of up to 100−200 GNPs per second. Among these features, absolute quantification provides a distinct advantage because it does not require standard samples.

Shaobin Zhu, Lingling Yang, Yao Long, Min Gao, Tianxun Huang, Wei Hang and Xiaomei Yan*, “Size Differentiation and Absolute Quantification of Gold Nanoparticles via Single Particle Detection with a Laboratory-Built High-Sensitivity Flow Cytometer”J. Am. Chem. Soc., 2010, 132(35), pp 12176–12178

 

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