杨朝勇
职称:副系主任
电话:0592-2187601
Email:cyyang@xmu.edu.cn
备注:博导
首页 >> 科研团队 >> 杨朝勇  简介
:: 个人简历

2008年1月至今,厦门大学化学化工学院,教授,博导 

2006年9月至2007年12月,加州大学伯克利分校化学系, 博士后 

2001年8月至2006年8月,美国佛罗里达大学,生物分析化学,博士 

1994年9月至2001年7月,厦门大学化学系,本科,硕士

:: 工作方向

1、特异性生物分子识别研究

2、微流控技术在生物医学中的应用

3、纳米生物医学工程

4、DNA纳米组装和信号放大

5、单细胞研究技术

:: 承担的基金

1、国家自然科学青年基金,用于细胞内基因成像的新型分子信标的设计与合成,09-11年

2、福建省自然科学基金,肿瘤干细胞的适体筛选及其在癌症研究和治疗的应用,08-11年

3、教育部博士点新教师基金,高通量单细胞基因分析的液滴微流控技术,09-11年

4、教育部留学回国人员科研启动基金,用于活细胞内mRNA成像的分子探针,08-11年

5、科技部973课题,增强拉曼光谱、电化学及联用技术应用于单细胞实时研究,07-11年

6、科技部973课题,核酸适体分子识别体系的设计与生物标志物的甄定,10-14年

:: 代表性文章

Lin, H.; Zou, Y.; Huang, Y.; Chen, J.; Zhang, W.; Zhuang, Z.; Jenkins, G.; Yang, C. *; DNAzyme Crosslinked Hydrogel: A New Platform for Visual Detection of Metal Ions, Chem. Commun., 2011, DOI:10.1039/C1CC12290H.

Fang, X.; Cai, Y.; Liu, J.; Wang, Z.; Wu, Q.; Zhang, Z.; Yang, C.; Yuan, L.; Ouyang, G. *;Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal,Oncogene, 2011,Inpress

Wang, K.; You, M.; Chen, Y.; Han, D.; Zhu, Z. Huang, J.;Williams, K.; Yang, C. *; Tan, W. * ; Self-assembly of a Bifunctional DNA Carrier for Drug Delivery, Angew. Chem. Int. Ed Engl. 2011, 50, DOI: 10.1002/anie.201008053.

Wang, X; Song, X.; He, C.; Yang, C. Chen, G.; Chen, X.; Preparation of Reversible Colorimetric Temperature Nanosensors and Their Application in Quantitative Two-Dimensional Thermo-Imaging; Anal Chem., 2011, 83, 2434–2437

Wang, C.; Zhu, Z.; Song, Y.; Lin H.; Yang C. *; Tan, W*; Caged molecular beacons: controlling nucleic acid hybridization with light, Chem. Commun., 2011, 47 (20), 5708 - 5710

Hu, J.; Wu,J.; Li,C.; Zhu, L.; Zhang,W.; Kong, G.; Lu Z. *; Yang, C. *; A G-quadruplex Aptamer Inhibits the Phosphatase Activity of Oncogenic Protein Shp2 in vitro, ChemBioChem, 2011,  12, 424 –430

Cui, L.; Ke, G.; Zhang, W.; Yang, C. *;  A Universal Platform for Sensitive and Selective Colorimetric DNA Detection Based on Exo III Assisted Signal Amplification, Biosensors and Bioelectronics, 2011, 26, 2796–2800

Huang, J.; Wu, Y.; Chen, Y.;, Zhu, Z.; Yang, X.; Yang, C.*; Wang, K. *; Tan, W. *; Pyrene Excimer Probes for Nucleic Acids in Complex Biological Fluids Based on Hybridization Chain Reaction Amplification, Angew. Chem. Int. Ed Engl. 2011, 50,401-404

Wang, C.; Wu ,C.; Chen, Y; Song, Y; Tan, W; Yang, C.*, Pyrene Excimer for DNA Sensors, Current Organic Chemistry,2011, 15(4), 465-476

Chen, Y.; O'Donoghue, M.; Huang, Y.; Kang, H.; Phillips, J.; Chen, X; Estevez, M.; Yang, C.; Tan, W. *,A Surface Energy Transfer Nanoruler for Measuring Binding Site Distances on Live Cell Surfaces, J. Am. Chem. Soc., 2010, 132 (46), 16559–16570

Li, D.; Guan, Z.; Zhang, W.; Zhou X.; Zhuang, Z.; Wang, X. and Yang, C.* , Synthesis of Uniform-size Hollow Silica Microspheres through Interfacial Polymerization in Monodisperse Water-in-oil Droplets,ACS Applied Materials & Interfaces, 2010, 2(10), 2711-2713

Wu, C.; Hu, J.; Zou, Y. A.; Wang, C.; Liu, J.*; Yang, C.*. Application of Aptamers in Biomedicine. Progress in Chemistry 2010, 22 (8), 1518-1530. (Invited Review)

 Ouyang, G.; Wang, Z.; Fang, X. and Yang, C.; Molecular Signaling of the Epithelial to Mesenchymal Transition in Generating and Maintaining Cancer Stem Cells, Cellular and Molecular Life Sciences, 2010, 67, 2605-2618

Leng, X.; Zhang, W.; Wang, C.; Cui, L,; Yang, C. *, Agarose Droplet Microfluidics for Highly Parallel and Efficient Single Molecule Emulsion PCR, Lab Chip 2010, 10(21),2841-2843. (Inside Cover),(Top Ten Accessed Paper, 2010 September)

Cui, L.; Ke, G.; Wang, C.;Yang, C.*, A Cyclic Enzymatic Amplification Method for Sensitive and Selective Detection of Nucleic Acids, Analyst. 2010, 135,2069-2073

Wu ,C.; Yan, L.; Wang, C.; Wang, C.; Chen, X.; Yang, C.*, A General Excimer Signaling Approach for Aptamer Sensors, Biosensors and Bioelectronics, 2010, 25(10), 2232-2237.

Zhu, Z.; Wu C.; Liu H.; Zou Y.; Zhang X.; Kang H.; Yang C.*; Tan W.*, Aptamer-Crosslinked Hydrogel as a Colorimetric Platform for Visual Detection. Angew. Chem. Int. Ed Engl. 2010,49(2)1052 –1056(Frontipiece Paper)

Yang, C.;Tan, W., Understanding Bioanalytical Chemistry: Principles and Applications. By Victor A. Gault and Neville H. McClenaghan. ChemBioChem, 2010, 11(3), 434.

Wu ,C.; Wang, C.;Yan, L.; Wang, C.; Yang, C.* Pyrene Excimer Nucleic Acid Probes for Biomolecule Signaling. J. of Biomed. Nanotech. 2009, 5. 495–504

Zhang, W.; Lin, S.; Wang, C.; Hu, J.; Li, C.; Zhuang, Z.; Zhou, Y.; Mathies, R. A. *; Yang, C.* PMMA/PDMS valves and pumps for disposable microfluidics. Lab Chip 2009, 9 (21), 3088-3094

  Wang, K.; Tang, Z.; Yang, C.; Kim, Y.; Fang, X.; Li, W.; Wu, Y.; Medley, C. D.; Cao, Z.; Li, J.; Colon, P.; Lin, H.; Tan, W. Molecular engineering of DNA: molecular beacons. Angew. Chem. Int. Ed Engl. 2009, 48 (5), 856-870.

Martinez, K.; Medley, C. D.; Yang, C.; Tan, W. Investigation of the hybrid molecular probe for intracellular studies. Anal. Bioanal. Chem. 2008, 391 (3), 983-991.

Kumaresan, P.; Yang, C.; Cronier, S. A.; Blazej, R. G.; Mathies, R. A. High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets. Anal. Chem. 2008, 80 (10), 3522-3529. (First coauthor)

Wu, Y.; Yang, C.; Moroz, L. L.; Tan, W. Nucleic acid beacons for long-term real-time intracellular monitoring. Anal. Chem. 2008, 80 (8), 3025-3028.

Chen, Y.; Yang, C.; Wu, Y.; Conlon, P.; Kim, Y.; Lin, H.; Tan, W. Light-switching excimer beacon assays for ribonuclease H kinetic study. Chembiochem. 2008, 9 (3), 355-359.

Conlon, P.; Yang, C.; Wu, Y.; Chen, Y.; Martinez, K.; Kim, Y.; Stevens, N.; Marti, A. A.; Jockusch, S.; Turro, N. J.; Tan, W. Pyrene excimer signaling molecular beacons for probing nucleic acids. J. Am. Chem. Soc. 2008, 130 (1), 336-342.

Kim, Y.; Yang, C.; Tan, W. Superior structure stability and selectivity of hairpin nucleic acid probes with an L-DNA stem. Nucleic Acids Res. 2007, 35 (21), 7279-7287.

Yang, C.; Wang, L.; Wu, Y.; Kim, Y.; Medley, C. D.; Lin, H.; Tan, W. Synthesis and investigation of deoxyribonucleic acid/locked nucleic acid chimeric molecular beacons. Nucleic Acids Res. 2007, 35 (12), 4030-4041.

Yang, C.; Martinez, K.; Lin, H.; Tan, W. Hybrid molecular probe for nucleic acid analysis in biological samples. J. Am. Chem. Soc. 2006, 128 (31), 9986-9987.

Shangguan, D.; Li, Y.; Tang, Z.; Cao, Z. C.; Chen, H. W.; Mallikaratchy, P.; Sefah, K.; Yang, C.; Tan, W. Aptamers evolved from live cells as effective molecular probes for cancer study. Proc. Natl. Acad. Sci. U. S. A 2006, 103 (32), 11838-11843.

Yang, C.; Li, J. J.; Tan, W. Using molecular beacons for sensitive fluorescence assays of the enzymatic cleavage of nucleic acids. Methods Mol. Biol. 2006, 335, 71-81.

 Liu, H.; Wang, H.; Shi, Z.; Wang, H.; Yang, C.; Silke, S.; Tan, W.; Lu, Z. TaqMan probe array for quantitative detection of DNA targets. Nucleic Acids Res. 2006, 34 (1), Art. No. E4

Tan, L.; Li, Y.; Drake, T.; Moroz, L.; Wang, K.; Li, J.; Munteanu, A.; Yang, C.; Martinez, K.; Tan, W. Molecular beacons for bioanalytical applications. Analyst 2005, 130 (7), 1002-1005.

Yang, C.; Medley, C. D.; Tan, W. Monitoring nucleic acids using molecular beacons. Curr. Pharm. Biotechnol. 2005, 6 (6), 445-452.

Yang, C.; Jockusch, S.; Vicens, M.; Turro, N. J.; Tan, W. Light-switching excimer probes for rapid protein monitoring in complex biological fluids. Proc. Natl. Acad. Sci. U. S. A 2005, 102 (48), 17278-17283.

Wang, L.; Yang, C.; Medley, C. D.; Benner, S. A.; Tan, W. Locked nucleic acid molecular beacons. J. Am. Chem. Soc. 2005, 127 (45), 15664-15665.

Yang, C.; Lin, H.; Tan, W. Molecular assembly of superquenchers in signaling molecular interactions. J. Am. Chem. Soc. 2005, 127 (37), 12772-12773.

Yang, C.; Pinto, M.; Schanze, K.; Tan, W. Direct synthesis of an oligonucleotide-poly(phenylene ethynylene) conjugate with a precise one-to-one molecular ratio. Angew. Chem. Int. Ed Engl. 2005, 44 (17), 2572-2576.

Bagwe, R. P.; Yang, C.; Hilliard, L. R.; Tan, W. Optimization of dye-doped silica nanoparticles prepared using a reverse microemulsion method. Langmuir 2004, 20 (19), 8336-8342.  

Wang, L.; Yang, C.; Tan, W. Dual-luminophore-doped silica nanoparticles for multiplexed signaling. Nano Lett. 2005, 5 (1), 37-43.  

Huang, Z.; Yang, C.; Zhuang, Z.; Wang, X.; Lee, F. S. C. Determination of trace lead in the high salt matrix of comestible CaCO3 by an isotope dilution method with detection by inductively coupled plasma-mass spectrometry. Analytica Chimica Acta 2004, 509 (1), 77-82.

Yang, C.; Huang, Z.; Zhao, L.; Zhuang, Z.; Wang, X. Isotope dilution inductively coupled plasma mass spectrometery for the determination of lead in plants and human hair. Chemical Journal of Chinese Universities-Chinese 2002, 23 (9), 1688-1691.

Wu, X.; Sun, D.; Yang, C.; Zhuang, Z.; Wang, X. Speciation of 9 trace elements in a traditional Chinese medicine Long Dan Cao by flow injection-inductively coupled plasma mass spectrometry with a focused microwave assisted extraction system. Spectroscopy and Spectral Analysis 2002, 22 (1), 75-78.

Huang, H.; Zhuang, Z.; Zhang, W.; Hu, J.; Yang, C.; Wang, X.. Application of Electrical Driven and Cationic Exchange Membrane to Capture and Enrich Deoxyribonucleic Acid. Chinese Journal of Analytical Chemistry 2010, 38 (1), 143-146.

Yang, C.  Wu, X.; Gu, S.; Zhuang, Z.; Wang, X. Hyphenation of C-18 gel silica column and flow injection with inductively coupled plasma-mass spectrometry and its application on the seawater analysis. Chinese Journal of Analytical Chemistry 2001, 29 (3), 283-286.

Yang, C. Chen F.; Zhuang Z.; Gu S.; Wang X. Determination of trace lead in high salt-containing samples by solid phase extraction column (SPE) - inductively coupled plasma mass spectrometer (ICP-MS).     J. of Xiamen Univ.(Natural Science) (2001),  40(5),  1062-1066.

Hu, G,Cai,Y.; Yang, C.; Wang, X.; Huang, Y.; Determination of 27 elements in two polymetallic nodule reference samples from the Pacific Ocean by ICP-MS.    Haiyang Xuebao   (2002),  24(1),  47-52.  

Yang, C.; Zhuang Z.; Gu S.; Chen F.; Wu X.; Application of isotope dilution-inductively coupled plasma mass spectrometry on trace element analysis. J. of Instrumental Analysis (2001), 20(2), 87-92.  

Yang, C.; Chen, B.; Zhuang, Z,; Zhao, L.; Wang X. Determination of Trace As, Sb and Bi in the Traditional Chinese Medicine (TCM) with Movable Reducing Bed Hydride Generator (MRBHG) and Inductively Coupled Plasma-Mass spectrometer (ICP-MS), Chem. J. Chin. Univ., 1999,20(5)

:: 获奖情况

2005年度中国国家优秀自费留学生奖(2006)

美国化学会分析化学研究生奖(2005, Merck&Co.)

:: 学术职务

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