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卢嘉锡讲座：RNA Topological Structures Using Small Angle X-Ray Scattering
【来源】：本站原创 【发表时间】：2017-3-28 【浏览次数】：
题    目: RNA Topological Structures Using Small Angle X-Ray Scattering

讲座人: 王运星 研究员
             美国国立卫生研究院癌症研究所
             NCI小角散射研究中心主任

时   间: 4月10日（周一）上午10:00-12:00

地   点: 卢嘉锡楼202报告厅

             欢迎各位老师同学积极参加！

嘉宾介绍：
      王运星博士是国际著名的结构生物学专家、美国国立卫生研究院癌症研究所小角散射研究中心主任。他在RNA的溶液结构、功能及其方法学研究等方面颇有建树，曾发展了多种研究RNA溶液结构的新方法，具有一定的国际影响力，是目前国际上很活跃的RNA结构生物学研究的领军人物之一。近三年来，他作为通讯作者在Cell,Nature, Nature Chem Biol，Curr. Opn. Str. Biol.和JACS等国际著名学术刊物上发表了多篇有国际影响的研究论文。他多次主持RNA结构与功能研究相关的国际学术会议和workshop。2014和2016年,他分别获得“NIH-Award of Merit”,“NIH, National Heart, Lung, and Blood Institue-Outstanding Basic Science Award”和“NIH-NIH Director Award for Outstanding Achievement in Medical and Science”等奖项，并主持过多项重要的科研基金项目。

报告摘要：
Detailed understanding of the structure and function relationship of RNA requires knowledge about RNA three-dimensional (3D) topological folding. However, there are very few unique RNA entries in structure databases. This is due to challenges in determining 3D structures of RNA using conventional methods, such as X-ray crystallography and NMRspectroscopy, despite significant advances in both of these technologies. Computational methods have come a long way in accurately predicting the 3D structures of small (<50 nt) rnas to within a few angstroms compared to their native folds. however, lack of an apparent correlation between an rna primary sequence and its 3d fold ultimately limits the success of purely computational approaches. in this context, small angle x-ray scattering (saxs) serves as a valuable tool by providing global shape information of rna. in this article, we review the progress in determining rna 3d topological structures, including a new method that combines secondary structural information and saxs data to sample conformations generated through hierarchical moves of commonly observed rna motifs. 

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