:: 个人简历 |
山西大学生物科学与技术学院生物化学理学学士(1996-2000); 山西大学生物技术研究所生物化学与分子生物学理学博士(2000-2005) 中科院上海药物研究所助理研究员(2005-2008); 美国马里兰大学化学与生物化学系博士后(2008-2010); 厦门大学化学与化工学院化学生物化学系副教授(2010-). |
:: 工作方向 |
蛋白质和多肽的结构与功能研究 |
:: 承担的基金 |
1.国家自然科学基金面上项目(No.31670741),人朊病毒蛋白G127V多态性保护作用的结构基础,2017/01-2020/12,在研,参与。 2.国家重点研发计划(No.2016YFA0500602),核糖体蛋白翻译后修饰调控网络及新调节因子功能研究,2016/07–2021/06,在研,参与。 3.国家自然科学基金面上项目(No.31470034),Raf1激酶抑制蛋白RKIP与配体的复合物溶液结构和功能研究,2015/01-2016/12,已结题,主持。 4.福建省自然科学基金面上项目(No.2011J01246),用NMR技术研究腺苷酸激酶AK1在催化过程中构象和动力学的变化,2011/04–2014/06,已结题,主持。 5.国家自然科学基金青年项目(No30900233),RKIP磷酸化交叉调控MAPK信号通路与GPCR信号通路的分子机制和结构基础,2010/01-2012/12,已结题,主持。 |
:: 代表性文章 |
(1)Chenyun Guo#, Yihang Xiao#, Fangkai Bi, Weiliang Lin, Huilin Wang, Hongwei Yao, Donghai Lin*, Recombinant expression, biophysical and functional characterization of ClpS from Mycobacterium tuberculosis,Acta Biochimica et Biophysica Sinica (Shanghai), 2019, 51(11): 1158-1167. (2)Chenyun Guo,Ting Chang, Tao Sun, Zhihua Wu, Yazhuang Dai, Hongwei Yao, Donghai Lin*Anti-leprosy drug Clofazimine binds to human Raf1 kinase inhibitory protein and enhances ERK phosphorylation,Anti-leprosy drug Clofazimine binds to human Raf1 kinase inhibitory protein and enhances ERK phosphorylation. 2018, 50(10): 1062-1067. (3)Shuangliang Tian, Hanyu Chen, Tao Sun, Huilin Wang, Xu Zhang, Yan Liu, Jinmei Xia,Chenyun Guo*, Donghai Lin*,Expression, purification and characterization of Esx-1 secretion-associated protein EspL from Mycobacterium tuberculosis.Protein Expression and Purification,2016, 128: 42-51. (4) Hanyu Chen,Huilin Wang,Tao Sun,Shuangliang Tian,Donghai Lin,Chenyun Guo*, Recombinant preparation and functional studies of EspI ATP binding domain from Mycobacterium tuberculosis,Protein Expression and Purification, 2016, 123: 51-59. (5) Tao Sun, Zhihua Wu, Mengyao Luo, Donghai Lin,Chenyun Guo*,Pranlukast, a novel binding ligand of human Raf1 kinase inhibitory protein.Biotechnology Letters,2016, 38(8):1375-1380. (6) Kejiang Lin, Ziyao Yu, Yuanhui Yao, Xinli Liao, Pei Huang,Chenyun Guo*,Donghai Lin*, Distinct effects of Cu2+-binding on oligomerization of human and rabbit prion proteins,Acta Biochimica et Biophysica Sinica (Shanghai),2015, 47(10):842-850. (7)Chenyun Guo#, Cuiying Yi#, Yu Peng, Yi Wen, Donghai Lin*, Solution structure and backbone dynamics of human Raf-1 kinase inhibitor protein,Biochemical and Biophysical Research Communications,2013, 438(1): 129-132. (8)Chenyun Guo, Raquel Godoy-Ruiz, Vitali Tugarinov*, High resolution measurement of methyl13C(m)-13C and1H(m)-13C(m) residual dipolar couplings in large proteins,Journal of the American Chemical Society, 2010, 132(40):13984-139847. (9)Chenyun Guo, Vitali Tugarinov*, Selective1H-13C NMR spectroscopy of methyl groups in residually protonated samples of large proteins,Journal of Biomolecular NMR, 2010, 46(2):127-33. (10)Chenyun Guo,Vitali Tugarinov*, Identification of HN-Methyl NOEs in large proteins using simultaneous amide-methyl TROSY-based Detection,Journal of Biomolecular NMR, 2009, 43(1): 21-30. (11)Chenyun Guo,Hua Diao, Yandong Lian, Hongyu Yu, Hongchang Gao, Yonglian Zhang, Donghai Lin*, Recombinant expression and characterization of an epididymis-specific antimicrobial peptide BIN1b / SPAG11E,Journal of Biotechnology, 2009, 139(1): 33-37. (12)Chenyun Guo,Chun Geng, Vitali Tugarinov*, Selective backbone labeling of proteins using 1,2-13C2-pyruvate as carbon source,Journal of Biomolecular NMR, 2009, 44(3):167-173. (13)Chenyun Guo,Daoning Zhang, Vitali Tugarinov*, A NMR experiment for simultaneous TROSY –baseddetection of amide and methyl groups in large proteins,Journal of American Chemical Society, 2008, 130(33): 10872-10873. (14)Chenyun Guo,Zhuoyi Li, Jingming Yuan*, Preparation of an immunoadsorbent coupled with a recombinant antigen to remove anti-acetylcholine receptor antibodies in abnormal serum,Journal of Immunological Method, 2005, 303: 142-147. (15)Chenyun Guo,Zhuoyi Li, Yawei Shi, Mingqun Xu, John G. Wise, Wolfgong E. Trommer, Jingming Yuan*, Intein-mediated fusion expression, high efficient refolding and one-step purification of gelonin toxin,Protein Expression and Purification, 2004, 37: 361-367. |
:: 获奖情况 |
:: 学术职务 |